The study of how miRNA regulates gene expression is cutting edge research, of which the mechanism still aims to be elucidated. I was deeply interested in how the use of bioinformatics and genome-wide analyses powers this type of research in the search for the regulation behind inhibitory strategies. Let-7 was the focus of this talk, and the study of how it is essential for normal development, and has even been linked to cancer in humans, which was surprising as this seems like a very novel mechanism in the development of cancer. Additionally, cellular differentiation was an interesting concept that was mentioned, and I wonder if it would be possible to use in a diverse set of applications, ranging from biomaterials to immunologic. The study of transcriptional and processing events which grant temporal-spatial control of miRNA expression was also very interesting, and reminded me of the topics we have covered in cellular differentiation, polarity, and the differential control of transcription.
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